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AlzRisk Paper Detail
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Reference: Kim, 2008
Cohort: Older adults in Kwangju, South Korea
Risk Factor: Homocysteine


Exposure Detail
"Blood samples at baseline and follow-up were collected in a fasting state and were carried out in the mornings where possible. They were placed into EDTA tubes and centrifuged, separated into plasma aliquots and stored at 27 degrees Celsius within 2 h of collection."

Serum concentrations of total plasma homocysteine were measured by high performance liquid chromatography (AxSYM Homocysteine Reagent Pack; Abbott Laboratories, USA)

Change in plasma homocysteine levels over the follow-up period was categorized into ordinal quintiles for the analysis. The change in plasma homocysteine in the study population ranged from a 20-μmol/L decrease to a 25-μmol/L increase. However, the range of values for the individual quintiles was not given.

Screening and Diagnosis Detail
Screening Method:
CDRClinical Dementia Rating (Berg 1988) (CDR)
MMSEMini-Mental State Examination (Folstein 1975)
Neuropsych Testing
Other

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Investigators used the Korean version of the MMSE and the Instrumental Activities of Daily Living Scale to screen AD and dementia cases.

Covariates & Analysis Detail
Analysis Type:
Logistic regression

The effect estimates were computed per increase in one ordinal quintile of plasma homocysteine change over the follow-up period.

AD Covariates:
Aage
Eeducation
Ggender
ALCalcohol intake
DEPdepression
DISABdisability
PAphysical activity
CRTserum creatinine
VITSsupplemental vitamin intake
VARSvascular risk score
WTCHweight change

TD Covariates:
Aage
Eeducation
Ggender
ALCalcohol intake
DEPdepression
DISABdisability
PAphysical activity
CRTserum creatinine
VITSsupplemental vitamin intake
VARSvascular risk score
WTCHweight change