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AlzRisk Paper Detail
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Reference: Tolppanen, 2015
Cohort: North Karelia Project/FINMONICA/Cardiovascular Risk Factors, Aging, and Dementia
Risk Factor: Physical Activity


Exposure Detail
"LTPA [leisure time physical activity] was assessed at all examinations with the question: 'How often do you participate in leisure-time physical activity that lasts at least 20–30 minutes and causes breathlessness and sweating?' Response options were (1) 'daily'; (2) '2–3 times a week'; (3) 'once a week'; (4) '2–3 times a month'; (5) 'a few times a year'; and (6) 'never due to illness or injury.' Because of low frequencies in some response categories, midlife LTPA was recoded into a three-category variable indicating high (responses 1 and 2), moderate (responses 3 and 4), and low (responses 5 and 6) levels of LTPA in
midlife."

Ethnicity Detail
Investigators do not provide data on ethnicity. All residents lived in or around the towns of Kuopio and Joensuu, Finland.

Screening and Diagnosis Detail
Screening Method:
CERADConsortium to Establish a Registry for Alzheimer's Disease (Morris 1989)
Informant interview
MMSEMini-Mental State Examination (Folstein 1975)

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: Dementia via DSM-IV.

Covariates & Analysis Detail
Analysis Type:
Other

"Because of variable follow-up times and an exponential increase in dementia risk with age, we fitted a parametric survival model with Gompertz distributed baseline intensity using the streg command in
Stata."

AD Covariates:
Aage
Eeducation
Ggender
ASMasthma
AFatrial fibrillation
BMIbody mass index
CVDcardiovascular disease
CVScardiovascular surgery
JNTPNchronic joint pain
CPDchronic pulmonary disease
CHFcongestive heart failure history
CADcoronary artery disease
DMdiabetes mellitus
MSmarital status
MImycardial infarction history
OPAoccupational physical activity
Oother
PAphysical activity
RArheumatoid arthritis
SMsmoking status
SHstroke history

TD Covariates:
Aage
Eeducation
Ggender
ASMasthma
AFatrial fibrillation
BMIbody mass index
CVDcardiovascular disease
CVScardiovascular surgery
JNTPNchronic joint pain
CPDchronic pulmonary disease
CHFcongestive heart failure history
CADcoronary artery disease
DMdiabetes mellitus
MSmarital status
MImycardial infarction history
OPAoccupational physical activity
Oother
PAphysical activity
RArheumatoid arthritis
SMsmoking status
SHstroke history