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Non-Steroidal Anti-Inflammatory Drugs
Chicago Health and Aging Project
Vitamin intake was measured using the baseline questionnaire, a modified Harvard food frequency questionnaire (FFQ) inquiring about usual intake during the past year of 139 food items and vitamin supplements.
Participants were community residents froma geographically defined biracial population on the south side of Chicago.
Screening and Diagnosis Detail
Consortium to Establish a Registry for Alzheimer's Disease (Morris 1989)
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
"Alzheimer’s disease was diagnosed on the basis of structured clinical evaluations that were conducted in participants’ homes by a team consisting of a neuropsychological technician, nurse clinician, phlebotomist, and neurologist. All team members were blinded to dietary and other participant information. The 2 to 3-hour evaluations included neuropsychological testing (using tests of the Consortium Established for Research on Alzheimer’s Disease, CERAD ), a complete medical history, medication use, laboratory testing, and neurological examination. Informant interviews were conducted for cognitively impaired participants. The diagnosis of probable Alzheimer’s disease was based on criteria of the joint working group of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and
Associated Disorders Association ."
Covariates & Analysis Detail
Nutrient intake was adjusted for total energy intake using the residual method (Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124:17-27).
APOE e4 genotype
dietary vitamin E
follow up time
Past Cognitive Activity
Models included an interaction term between race (African-American /Caucasian) and APOE ε4 status (any ε4 alleles/none).