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Papers of the Week
The HBO Alzheimer's Project
My AlzForum Home
AlzRisk Paper Detail
Non-Steroidal Anti-Inflammatory Drugs
Alzheimer's Disease Anti-inflammatory Prevention Trial
Average Follow-up Time Detail
Members of the cohort were followed for up to 3.75 years. The article does not provide the average follow-up time for the participants.
The interviewers ascertained exposure by recording self-reported statin use at each visit.
The investigators compared incident AD risk in two groups: the group of participants who consistently used statins during follow-up ("Consistently used") and the reference group of participants who did not use statins or non-statin LLAS ("Never used").
The participants of the ADAPT trial were predominantly Caucasian (97%). Few participants were African-American. The article did not report the ethnicity breakdown of the sample used for this analysis.
Screening and Diagnosis Detail
Cognitive Assessment Battery Testing
Mini-Mental State Examination (Folstein 1975)
Diagnostic and Statistical Manual IV
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition:
Dementia via DSM-IV
Covariates & Analysis Detail
Cox proportional hazards regression
APOE e4 genotype