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AlzRisk Paper Detail
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Reference: Rea, 2005
Cohort: Cardiovascular Health Cognition Study/Cardiovascular Health Study Cognition Study
Risk Factor: Statin use


Exposure Detail
The interviewers ascertained exposure information via an annual medication inventory. The investigators reported results separately for ever/never statin use, lipophilic statin use, less lipohilic statin use, current/past/never use, and duration of use. This entry pertains to results on duration of statin use.

The investigators compared incident AD risk in three separate sets of comparison groups: the group of participants who used statins for less than a year ("< 1 year") and the reference group of participants who did not use statins or non-statin LLAs ("Never used"); the group of participants who used statins between one to three years ("1-3 years") and the reference group of participants who did not use statins or non-statin LLAs ("Never used"); and the group of participants who used statins for more than three years ("> 3 years") and the reference group of participants who did not use statins or non-statin LLAs ("Never used"). The article does not provide the exposure distribution for the study cohort in regards to duration of statin use.

Ethnicity Detail
Caucasian participants contributed 91% of person-time.

Age Detail
Cohort members older than eighty years of age contributed 54% of person-time. The article does not provide the average age for members of this cohort.

Screening and Diagnosis Detail
Screening Method:
Brain Imaging
MMSEMini-Mental State Examination (Folstein 1975)
Other

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:
Aage
Eeducation
Ggender
MMSEbaseline MMSE
BSTRbaseline stroke
BCHDbasline CHD

TD Covariates:
Aage
Eeducation
Ggender
MMSEbaseline MMSE
BSTRbaseline stroke
BCHDbasline CHD