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Reference: Ancelin, 2012b
Cohort: Three-City Study
Risk Factor: Non-Steroidal Anti-Inflammatory Drugs


Average Follow-up Time Detail
The median follow-up time (IQR) was 6.7 (3.8-7.2) years.

Exposure Detail
Investigators ascertained exposure information by administrating a standardized interview and by examining prescriptions and medications at baseline and at follow-up visits. The investigators reported results on current vs. not using non-ASA NSAIDs separately for male and female participants. This entry pertains to results among women.

The investigators compared AD risk in two groups: the group of female participants who used non-ASA NSAIDs at baseline ("Current use") and the reference group of female participants who did not use non-ASA NSAIDs at baseline ("Not using").

Ethnicity Detail
The 3C cohort is composed of community-dwelling persons of 3 French cities. The distribution of other ethnic backgrounds was not reported.

Screening and Diagnosis Detail
Screening Method:
BVRTBenton Visual Retention Test (Benton 1974)
ISTIsaacs' Set Test (Isaacs & Kennie 1973)
MMSEMini-Mental State Examination (Folstein 1975)
TMTTrail Making Test (Reitan 1958)

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
Neurologic examination

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

"A Cox model with delayed entry was used in the analysis of dementia incidence taking age as the basic time scale and birth as the time origin."

AD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
ASMasthma
BRNbronchitis
JNTPNchronic joint pain
CCcity center
DEPdepression
DMdiabetes mellitus
HICAFhigh caffeine intake
HChigh cholesterol
IHDischemic heart disease
SMsmoking status

TD Covariates:
Aage
Eeducation
Ggender
APOE4APOE e4 genotype
ASMasthma
BRNbronchitis
JNTPNchronic joint pain
CCcity center
DEPdepression
DMdiabetes mellitus
HICAFhigh caffeine intake
HChigh cholesterol
IHDischemic heart disease
SMsmoking status