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Uppsala Longitudinal Study of Adult Men
Average Follow-up Time Detail
"All men born between 1920 and 1924 living in Uppsala county were invited to participate in a health examination
focusing on vascular risk factors at the age 50 years. Of
the 2,841 men invited, 2,322 (82%) participated in the baseline investigation. The subjects with missing data on any of the risk factors studied were excluded (n = 54), leaving 2,268 participants for the present study.
Participants were invited to a re-examination of vascular risk factors 20 years later. Of the 1,681 available 70-year-old men invited, 1,221 attended and 1,174 had all the necessary data for this study and no dementia at that time point."
Participants were followed for dementia until 2010.
This entry describes the association between systolic blood pressure at approximately age 70 and Alzheimer disease.
"Blood pressure was measured in the right arm with the subject in the supine position after resting for 10 minutes, and then after the subject had been standing for 2 minutes. The values was recorded twice and to the nearest even figure. The means of the two values are given for each blood pressure. The cuff size was 12·35 cm or 15·45 cm depending on the arm circumference. Systolic and diastolic blood pressure were defined as Korotkoff phases I and V, respectively. [http://www2.pubcare.uu.se/ULSAM/invest/70yrs/meth70.htm#03]"
All men were born within a 4 year period.
Screening and Diagnosis Detail
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
"The medical records of the ULSAM participants from all the
clinics of Uppsala University Hospital, the Uppsala general practitioners and nursing homes were reviewed until January 1, 2010 (censor date). Practically all medical care for the participants had been provided in these settings. The diagnoses of dementia were assigned by two experienced geriatricians independently, blinded from the baseline data, using all available data from these records. In case of disagreement, a third experienced geriatrician reviewed the case and the diagnosis was determined by majority decision. ... Cases of dementia without neuroimaging
and without sufficient clinical details in the medical records to set a specific dementia subtype diagnosis were classified as unspecified dementia."
Covariates & Analysis Detail
Cox proportional hazards regression