Alzforum: AlzRisk Paper Detail

AlzRisk Paper Detail

Risk Factors

Alcohol

Inflammatory Biomarkers

Non-Steroidal Anti-Inflammatory Drugs

Nutritional Antioxidants

Obesity

Physical Activity

Statin use

Reference:	Solfrizzi, 2010

Cohort:	Italian Longitudinal Study on Ageing

Risk Factor:	Blood Pressure

Average Follow-up Time Detail
"The subjects of this study took part in a larger study, the Italian Longitudinal Study on Ageing (ILSA), promoted by the Italian National Research Council, in which a sample of 5632 independent subjects 65–84 years old was randomly selected from demographic rolls of eight municipalities, after stratification for age and gender. Data were obtained from the first prevalence survey study between March 1992 and June 1993, and from the follow-up survey study between September 1995 and October 1996. The ILSA was described in detail elsewhere.5 The study population consisted of 2097 free-living elderly subjects, representing the 37.2% of randomly selected ILSA participants in 1992–1993 (n=5632), who underwent both a clinical examination and laboratory assessment."

Exposure Detail
Hypertension was defined as average measured blood pressure of at least 130/85 mm Hg or self-report of current antihypertensive medication use at baseline.

Screening and Diagnosis Detail
Screening Method:

Informant interview
MMSE	Mini-Mental State Examination (Folstein 1975)

AD Diagnosis:

NINCDS ADRDA

National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: DSM-III-R

"In phase 1, each subject was administered a screening questionnaire, a series of brief screening tests to identify suspect cases for further investigation, and clinical evaluation; in phase 2, suspected cases were confirmed with a standardised clinical examination by a certified neurologist or geriatrician. The main screening criteria for cognitive impairment or dementia were the MMSE with a cut-off score of ²³, or a previous diagnosis reported by the respondent proxy."

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

AD Covariates:

A	age
E	education
G	gender
ALC	alcohol intake
CAD	coronary artery disease
DEP	depression
FG	fibrogen
NHDL	non-HDL cholesterol
O	other
SM	smoking status
SH	stroke history

TD Covariates:

A	age
E	education
G	gender
ALC	alcohol intake
CAD	coronary artery disease
DEP	depression
FG	fibrogen
NHDL	non-HDL cholesterol
O	other
SM	smoking status
SH	stroke history