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AlzRisk Cohort Detail

Cohort: Hisayama Study
Risk Factors:

Introduction to the Cohort
The Hisayama study is a longitudinal study beginning in 1961 of cerebrovascular disease in a Japanese rural community, Hisayama town, which is adjacent to a metropolitan area of Fukuoka on Kyushu Island, Japan. The population of Hisayama has the distributions of age, occupational status, and nutrient intake similar to the general Japanese population. In 1985, 887 participants aged 65 years or older (94.6% of all residents in this age range) were screened for dementia; of those, 828 were free of dementia (334 men and 494 women). Information about new cardiovascular events, including stroke and neurologic symptoms, was collected through a daily monitoring system. Regular health assessments were also administered biennially. In 1992, investigators conducted a follow-up screening survey of all 614 surviving participants as part of the regular health check including a battery of neurophysiological tests; 577 participants underwent neuropsychological assessments.

Ethnicity Breakdown
All members of the Hisayama cohort are Japanese.

Diagnosis & Evaluation Methods
For a detailed description, see Ueda K et al. 1992.

Ueda K, Kawano H, Jasuo Y, Fujishima M. Prevalence and etiology of dementia in a Japanese community. Stroke. 1992;23:798-803.

Katsuki S. Epidemiological and clinicopathological study on cerebrovascular disease in Japan. Prog Brain res. 1966;21B:64-89.