Enter your keywords
HOME
About Us
NEWSLETTER
To search AlzRisk, use the "Keyword" search on the
AlzRisk search page
.
NEWS
All News
Conference Coverage
Series
WEBINARS
All Webinars
Databases
AlzBiomarker
AlzPedia
AlzRisk
Antibodies
Genetics
AlzGene
HEX
Mutations
Protocols
Research Models
Therapeutics
PAPERS
All Papers
Papers of the Week
Milestone
Alzforum Recommends
PROFESSIONAL RESOURCES
Conference Calendar
Grants
Jobs
Member Directory
ABOUT AD
AD Overview
Early-Onset Familial
The HBO Alzheimer's Project
Supported Browsers
MY ALZFORUM
My AlzForum Home
View Library
View Notifications
Set Notifications
Edit Profile
AlzRisk Paper Detail
Risk Factors
Alcohol
B Vitamins
Blood Pressure
Cognitive Activity
Diabetes Mellitus
Dietary Pattern
Head injury
Homocysteine
Hormone Therapy
Inflammatory Biomarkers
Non-Steroidal Anti-Inflammatory Drugs
Nutritional Antioxidants
Obesity
Physical Activity
Statin use
Reference:
van Oijen, 2005
Cohort:
Rotterdam Study
Risk Factor:
Inflammatory Biomarkers
Average Follow-up Time Detail
At the baseline examination between 1990-1993, 7047 people were screened for dementia and had blood samples drawn. 334 prevalent cases of dementia were excluded, leaving a cohort of 6713 at risk for dementia. Follow-up examinations occurred between 1993-1994, and again in 1997-1999. In addition, linkage with records of general practitioners allowed for continuous monitoring of the cohort for morbidity and mortality, resulting in complete follow-up through January 1, 2000.
Exposure Detail
"Fibrinogen levels were derived from the clotting curve of the prothrombin time assay using Thromborel S as a reagent on an automated coagulation laboratory (ACL 300, Instrumentation Laboratory). The coefficient of variation was 5%."
Fibrinogen measurements were done at baseline in a random sample and were available for 2835 of the persons at risk.
Ethnicity Detail
Study participants were residents of Ommoord, a suburb of the city of Rotterdam, the Netherlands
Age Detail
The age presented here is the average age at the start of follow-up, in the random cohort with fibrinogen measurements available.
Screening and Diagnosis Detail
Screening Method:
CAMDEX
Cambridge Examination for Mental Disorders of the Elderly
GMS
Geriatric Mental State Schedule (Copeland 1976)
MMSE
Mini-Mental State Examination (Folstein 1975)
AD Diagnosis:
NINCDS ADRDA
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition:
DSM-III-revised.
Screening:
(Described in
van Oijen et al. 2005
) "The diagnosis of dementia was made following a 3-step protocol. Two brief tests of cognition (Mini-Mental State Examination [10] and Geriatric Mental State schedule [11] organic level) were used to screen all of the subjects. Screen-positives (Mini-Mental State Examination score 26 or Geriatric Mental State organic level 0) underwent the Cambridge examination for mental disorders of the elderly (Camdex) [12]. Subjects who were suspected of having dementia were, if necessary, examined by a neuropsychologist. In addition, the total
cohort was continuously monitored for incident dementia through computerized linkage between the study database and digitalized medical records from general practitioners and the Regional Institute for Outpatient Mental Health Care."
Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression
Fibrinogen was normally distributed. This table displays the results for fibrinogen entered as a linear term in a Cox proportional hazards model. In Table 8, we provide the results for fibrinogen as quintiles.
AD Covariates:
A
age
G
gender
APOE4
APOE e4 genotype
ATH
atherosclerosis
BMI
body mass index
DM
diabetes mellitus
DBP
diastolic blood pressure
HDL
HDL cholesterol
SM
smoking status
SH
stroke history
SBP
systolic blood pressure
TC
total cholesterol
TD Covariates:
A
age
G
gender
APOE4
APOE e4 genotype
ATH
atherosclerosis
BMI
body mass index
DM
diabetes mellitus
DBP
diastolic blood pressure
HDL
HDL cholesterol
SM
smoking status
SH
stroke history
SBP
systolic blood pressure
TC
total cholesterol
In addition to the results we display here, the authors report results for another model that adjusts for age, sex, C-reactive protein, and white blood cell count. Results for both models are similar, so we display the results from the more fully-adjusted model.